Posttranslational Modifications of Pyruvate Kinase M2: Tweaks that Benefit Cancer
Cancer cells rewire metabolism to meet biosynthetic and energetic demands.The characteristic increase in glycolysis, i.e., Warburg effect, now exm1996 considered as a hallmark, supports cancer in various ways.To attain such metabolic reshuffle, cancer cells preferentially re-express the M2 isoform of pyruvate kinase (PKM2, M2-PK) and alter its quat